Innovation talks
Situated at the heart of the Expo Foyer, the Innovation Lab is the place to be where sponsors are showcasing their latest solution through a technical presentation, new product launches, and Q&A with attendees. The Innovation Lab also serves as the stage for the elevator pitches, to present startups and new innovators.
More information and the programme can be found below. Registration for the innovation talk is not needed, entrance is included in your registration fee.
Innovation talks are part of the IMSC 2022 sponsor opportunities, more information about these opportunities can be found on the sponsor page.
Innovation talks programme
Monday 29 August 2022
Chair of IMSC 2022: Richard Scheltema
14.45 - 15.00
Waters
Latest innovations to address challenges in Mass Spectrometry Imaging
Dr Steve Pringle
Consultant Research Scientist, Waters
Mass Spectrometry Imaging enables the spatial localisation of biomolecules in tissues, without the need of any prior knowledge of their presence and is a rapidly expanding field of mass spectrometry. However, there are still many challenges to address including improvements to spatial resolution, sensitivity, the molecular range that can be identified, the confidence with which analytes can be identified and the need for improved through-put.
Join this innovation talk to get an overview of the latest technologies from Waters that are helping to address these challenges and get a glimpse into future developments.
15.00 - 15.15
Refeyn
Innovative biomolecular characterization with mass photometry
Matthias Langhorst
Chief Product Officer, Refeyn
Mass photometry is an easy-to-use, single-molecule technology that can rapidly assess sample purity, binding affinities, complex assembly and much more. It needs no labels and very little sample and works for different types of biomolecules – from proteins and DNA to small viruses, such as AAVs.
In this innovation talk, we will explain how mass photometry works and show examples of what it can do.
15.15 - 15.30
Thermo Fisher Scientific
Improving Experimental Study Design to Accelerate Sample-to-Knowledge Workflows
Kristan Bahten, Sr. Product Marketing Manager, Thermo Fisher Scientific
Study design and evaluation of statistical parameters are critical steps throughout the workflow that can impact results and determine the impact of a study. This innovation talk will highlight a unique experimental design software and how it can integrate into your existing proteomics infrastructure
Tuesday 30 August 2022
Chair of IMSC 2022: Albert Heck
14.45 - 15.00
Waters
Development and implementation of Next generation time-of-flight for MRT
Dr. Emma Marsden-Edwards PhD
Advanced MS Technologies, Waters
Multi Reflecting Time of Flight (MRT) high mass resolution and <500ppb mass accuracy over a broad mass range independent of scan speed.
Attend this innovation talk as we detail this state-of-of the-art technology and the benefits it brings to a range of applications from LC-MS profiling of drugs, metabolites and proteins/ peptides to mass spectrometry imaging.
15.00 - 15.15
SCIEX
Leveraging the power of Zeno SWATH DIA for highly sensitive protein identification and quantitation
Heather Chassaing
Accurate Mass Workflow Specialist, SCIEX
The challenge for discovery proteomics techniques is to analyze as broadly and as deeply as possible to detect as many of the proteins and proteoforms present in the sample so that biological insights can be gained. This presentation will show that Zeno SWATH DIA increases proteomic depth and dynamic range by increasing the duty cycle of MSMS experiments by Zeno trapping. In addition, the ZenoTOF 7600 system has the speed necessary to be amenable to high chromatographic flow rates and fast gradients, providing the facility to carry out high-throughput proteomic experiments, even at low sample loads. Finally, this fast and robust system can be used with ‘library-free’ searches providing meaningful data faster than ever.
15.15 - 15.30
Shimadzu
Full Solution in MS Imaging – From Teaching to Routine
Ann-Christin Niehoff
European Innovation Center, Shimadzu Europa GmbH, Duisburg, Germany
Starting with solutions for samples preparation, via data acquisition to data analysis. A journey through the whole workflow for MS imaging with its newest technologies to learn and teach MALDI-MS and performing high throughput analysis without compromising accuracy, resolution and flexibility are explored.
Wednesday 31 August 2022
Chair of IMSC 2022: Isabelle Kohler
14.45 - 15.00
Bruker
Spatial Metabolite-ID in pharmaceutical applications
Dr. Tiffany Siegel, Scientist - Mass Spectrometry Imaging at Boehringer Ingelheim Pharma GmbH, Biberach an der Riss, Germany
Metabolite identification is an important step within drug discovery and development. Traditionally, LC-MS-based analytics of body fluids (e.g. plasma, bile, urine) are the dominant technology in this field. We show how metabolite detection in tissue can enhance this approach by combining LC-MS-based identification of metabolites from tissue homogenates with metabolite localization by MALDI-MSI on a single platform in a Spatial Omics-like scenario.
15.00 - 15.15
SCIEX
Using the ZenoTOF 7600 for complete characterization of Cell and Gene Therapy drugs and vaccines
Heather Chassaing
Accurate Mass Workflow Specialist
SCIEX
A complete qualitative assessment of a biotherapeutical products is essential not only during quality control but also during the drug development process. A streamlined approach is needed to obtain information on various attributes such as protein identification, sequence confirmation, identification of the nature and position of modifications, and the characterization of drug delivery systems. This thorough qualitative analysis needs to be reproducible, sensitive, and fast so that critical decisions can be made rapidly. Many approaches are based on characterization using collision-induced dissociation (CID), here, a novel fragmentation type based on EAD fragmentation, combined with Zeno trapping to boost sensitivity, can provide these structural insights rapidly and reproducibly. Allowing timely decision making and ensuring the efficacy and safety of biotherapeutic drug products.
15.15 - 15.30
Agilent
When time matters – Ion Mobility for Biopharma
Chris Klein
LC/Q-TOF Marketing Product Manager
Agilent Technologies
Ion Mobility adds a 4th dimension into LC/MS workflows, allowing to separate isobaric compounds as well as analyzing structural changes of biomolecules. Via Collision induced Unfolding (CIU) the stability of intact proteins can be analyzed in a much faster and more sensitive way than other analytical methods. A further Ion Mobility based technique suitable for Biopharma applications is high-resolution demultiplexing, leading with a resulting Ion Mobility resolution of over 200 to distinct arrival time distributions of glycans. These unique profiles can be used for the identification of glycans without further fragmentation.
Thursday 1 September 2022
Chair of IMSC 2022: Maarten Altelaar
14.45 - 15.00
Bruker
Applying Immunopeptidomics to predict clinical immunogenicity
Dr. Duong Nguyen, Octapharma Biopharmaceuticals GmbH, Berlin, Germany
Therapeutic proteins have the potential to induce an anti-drug antibody response that can neutralize the therapeutic effects and contribute to hypersensitivity in patients.
To assess the immunogenicity potential of our therapeutic candidates we apply immunopeptidomics for the identification of immunogenic hotspots and for unravelling the mechanisms that cause immunogenicity.
15.00 - 15.15
SCIEX
Improved Metabolite elucidation using a new Orthogonal Ion fragmentation
Ferran Sánchez, Senior Pharma/CRO & Aftermarket MDM EMEAI
This talk will introduce why deep structural elucidation of drug candidate metabolism is a requisite part of early- to late-stage drug discovery. Early studies are used to determine if a drug candidate is prone to metabolic breakdown or oxidation/conjugation.
This presentation showcases how both electron activated dissociation (EAD) utilizing a high-energy produces alternative fragments compared to CID. EAD generates a richer, more in depth fragmentation pattern than CID and can generate site specific spectral peaks for labile fragments that would otherwise be lost.
15.15 - 15.30
Aspect Analytics NV
Supporting high-throughput mass spectrometry imaging via dedicated software
Marc Claesen
Chief Executive Officer, Aspect Analytics NV
Mass spectrometry imaging (MSI) is rapidly maturing into a staple technology to characterize the spatial distribution of a variety of biomolecular families. As instrumentation continues to improve in both speed and volume of information that is captured, dedicated software solutions are necessary to manage and analyze the resulting molecular imaging data.
In this innovation talk, we will illustrate how Aspect Analytics supports MSI labs in various application areas, including pharmaceutical research and diagnostics. We will discuss key challenges and opportunities that arise when operating in high-throughput settings, including data management, data-driven QC, facilitating collaboration between team members and comprehensively communicating scientific insights from MSI experiments to various stakeholders.
Lunch seminars
Lunch seminars are part of the IMSC 2022 sponsor opportunities. Sponsors have the opportunity to boost up and brand their business during their lunch seminar.
More information and the programme can be found below. Make sure you register for the lunch seminar as seats are limited. Free lunch is included as well.
lunch seminars programme
Monday 29 August 2022
13:00 - 14:00 CEST
Bruker
Room: 0.10
From Single Cell to plasma analysis: unleashing the potential of 4D-Proteomics™ to address biological challenges
Join us at IMSC2022. Meet our users, in-house experts and collaboration partners at our 4D-Proteomics™ seminar
Increasing the throughput of sensitive proteomics by plexDIA
Prof. Dr. Nikolai Slavov, Allen Distinguished Investigator and Associate Professor, Northeastern University, Boston, MA, USA
Real-time PASEF DDA and DIA data processing by PaSER™ for clinical applications
Dr. Hans Wessels, Proteomics scientist, Radboud University Medical Centre, Nijmegen, Netherlands
Crosslinked peptide analysis
Dr. Richard Scheltema from the Netherland Proteomics Centre; Utrecht, Netherlands
As they rely on the use of Parallel Accumulation Serial Fragmentation (PASEF) -based methods, 4D-Proteomics approaches are capable of acquiring peptide MS/MS spectra simultaneously with an extremely high acquisition speed, an increased selectivity and a best-in class sensitivity.
Moreover, an accurate Collisional Cross Section (CCS) is measured for each peptide: its use in the bioinformatic processing pipeline allows to further increase identification sensitivity and quantification accuracy. Learn how those approaches can be used to obtain more information from some of the most challenging proteomics task: from single-cell research to plasma-based diagnosis and crosslinked peptides analysis.
Register here.
Waters
Room: 0.11
Discover What's New and Exciting from Waters
- Markers for COVID-19 disease progression: Comprehensive LC-MS characterization of the metabolome
Clare Mills, Professor of molecular allergology at the University of Manchester
- Cyclic-IMS: a revolution in lipid isomer resolution
Stephen Blanksby, Professor of Chemistry at Queensland University of Technology
Register here.
Biognosys AG
Room: 0.4/0.5
SpectroDive 11: Straightforward Validation of Your Protein Targets
Véronique Laforte, Biongosys
Therese Dau, Leibniz Institute on Aging
Teresa Barth, Ludwig-Maximillian University of Munich
Targeted proteomics renders high sensitivity, accurate absolute quantification, and confident target validation. However, the preparation of the workflow and the validation of results can feel intimidating. SpectroDive 11 solves this by offering a seamless platform that supports you in every step of targeted analysis, including:
- Analytical runs and calibration curves for the determination of linear ranges and limits of detection and quantification
- Custom panel generation
- Refined scheduling and optimal method export
- Confident peak picking and automatic FDR control
- Quantification results automatically given in absolute numbers
This exciting lunch seminar will start off by taking you through the new features and improvements in the latest version of SpectroDive, including the addition of calibration curves, and ion mobility support for FAIMS-PRM and prm-PASEF. Then, you will learn from experts in the field why targeted proteomics is the approach of choice to answer certain biological questions, and how SpectroDive is a key tool for the realization of such experiments.
Register here.
Tuesday 30 August 2022
13:00 - 14:00 CEST
Bruker
Room: 0.10
Multimodal and Multiomics: Rethinking cancer metabolism trough MALDI Imaging
To target or not to target: translational imaging & “omics” of single cells
Prof. Dr. Ron Heeren, Director and Division Head Imaging Mass Spectrometry, Maastricht MultiModal Molecular Imaging Institute, M4i, Maastricht University, Maastricht, Netherlands
MALDI Imaging Mass Spectrometry in Pharmaceutical Research & Development
Prof. Dr. Carsten Hopf, Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Mannheim and Medical Faculties, Heidelberg University, Germany
Whether you are probing the cellular proteome, lipidome or metabolome, MALDI Imaging provides a literal map of molecular expression in the specimen that can be compared to reveal regional changes.
Often, knowing where molecular expression changes can be just as important as knowing if expression changes. This can be especially true if certain compounds are highly spatially concentrated or if molecules co-distribute in specific compartments, vital information that is lost when examining only homogenized samples.
Bruker offers solutions for targeted and untargeted discovery with the most complete molecular range and contextualized spatial information, providing important clues into intercellular communications networks that are integral to cancer growth.
Register here.
Thermo Fisher Scientific
Room: 0.11
New Tools for Confident Proteoforms and Macromolecules Analysis
Rosa Viner, Senior Manager, Vertical Marketing LSMS, Thermo Fisher Scientific
Tarick El-Baba, Senior Researcher Department of Chemistry, University od Oxford, United Kingdom
Detecting individual ion signals, rather than traditional packets of ions, advances Orbitrap-based resolution and charge detection capabilities. To this end, individual ion mass spectrometry alters spectral outputs directly into the Dalton domain to deconvolute complex protein mixtures and determine mass distributions for large particles ranging from 8 kDa to 6 MDa. This workshop will highlight new technologies coupled with easy-to-handle analysis software that advances charge detection capabilities and mass range of macromolecules that can be analyzed.
Register here.
Wednesday 31 August 2022
13:00 - 14:00 CEST
Thermo Fisher Scientific
Room: 0.11
A New Experience in Automated Proteomics Sample Preparation for Quantitative Proteomics
Daniel Lopez Ferrer, Director Proteomics and Translational Research, Thermo Fisher Scientific
Kay Oppermann, Senior Product Manager, Protein Analysis, Thermo Fisher Scientific
Break free from the time, cost, and complexity of manual sample preparation. This workshop will discuss the challenges of automated proteomics sample preparation and what is needed to overcome these so that scientists can achieve high quality experimental results and focus their time on more valuable tasks. Attributes such as ease-of-use, experimental design , flexible workflows, and integration into existing proteomics infrastructure will be discussed with the scientific community.
Register here.
Agilent
Room: 0.10
Latest Advances in Liquid Chromatography Mass Spectrometry
Part 1 - Carola Damen, Agilent Technologies NL
Part 1 - We present a novel Triple Quad LC/MS system, combining onboard instrument intelligence and productivity enhancing software workflows. The melding of instrument intelligence with robust hardware increases sample throughput whilst reducing maintenance times.
Part 2 - Chris Klein, Agilent Technologies US.
Strategies and developments for food safety and authenticity using high-resolution MS.
Register here.
Thursday 1 September 2022
13:00 - 14:00 CEST
Thermo Fisher Scientific
Room: 0.11
Intelligent data acquisition strategies for TMT multiplexed single cell proteomics applied on human hematopoiesis
Benjamin Furtwängler, Porse Group at Copenhagen University and Schoof Lab at the Technical University of Denmark (DTU)
TMT multiplexed proteomics is mandatory to go beyond analyzing one single cell at a time with high throughput and quantitative accuracy that enables several hundreds of cells to be analyzed per day in order to achieve biological insights. Real time search acquisition methods unique to Orbitrap Tribrid mass spectrometers have delivered two strategies that will provide new capabilities for TMT multiplexed single cell proteomics. Real time search-MS3 provides a much higher quantitative accuracy with similar proteome coverage to standard MS2 methods, this higher accuracy could be used to model protein networks. Here we will discuss the new RETICLE (real time search enhanced quant of single cell spectra) approach that makes use of fast real time searched ion trap scans to significantly improve proteome coverage over MS2 methods and hence high throughput applications such as building single-cell atlases.
Register here.
Agilent
Room: 0.10
Ready for Today, Prepared for Tomorrow with Agilent GC/MS solutions
Remko Van Loon, Agilent Technologies NL (part 1); Katrien Sabbe, Agilent Technologies BE (part 2).
The latest advancements in GC/MS technology:
- GC/MS technology to enhance lab productivity and performance
- Effectively reduce downtime
- Alternative Carrier Gas
Register here.